Drug interactions
Choline magnesium trisalicylate + Mefenamic acid
Severity: Moderate
Choline magnesium trisalicylate and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining mefenamic acid with a salicylate increases the risk of gastrointestinal irritation, ulceration and bleeding without adding meaningful benefit. Renal toxicity risk is also increased.
What this interaction means in plain words
Choline magnesium trisalicylate and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of cyclooxygenase, reducing gastroprotective prostaglandins and platelet function.
What to do
Avoid using two NSAID-type agents together; if unavoidable, add gastroprotection and monitor for GI bleeding and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Mefenamic acid?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining mefenamic acid with a salicylate increases the risk of gastrointestinal irritation, ulceration and bleeding without adding meaningful benefit. Renal toxicity risk is also increased.
How serious is the interaction between Choline magnesium trisalicylate and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two NSAID-type agents together; if unavoidable, add gastroprotection and monitor for GI bleeding and renal function.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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