Drug interactions
Choline magnesium trisalicylate + Mycophenolate mofetil
Severity: Moderate
Choline magnesium trisalicylate and Mycophenolate mofetil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylate can compete with mycophenolic acid glucuronide for renal tubular secretion and displace mycophenolic acid from albumin. Free mycophenolic acid may rise, and the combination adds GI and renal risk.
What this interaction means in plain words
Choline magnesium trisalicylate and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion and plasma protein binding displacement by salicylate.
What to do
Monitor for GI toxicity, cytopenias and renal function. Use the lowest effective salicylate dose or choose paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Choline magnesium trisalicylate with Mycophenolate mofetil?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylate can compete with mycophenolic acid glucuronide for renal tubular secretion and displace mycophenolic acid from albumin. Free mycophenolic acid may rise, and the combination adds GI and renal risk.
How serious is the interaction between Choline magnesium trisalicylate and Mycophenolate mofetil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI toxicity, cytopenias and renal function. Use the lowest effective salicylate dose or choose paracetamol.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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