Drug interactions
Choline magnesium trisalicylate + Piroxicam
Severity: Major
Choline magnesium trisalicylate and Piroxicam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two NSAIDs raises the risk of gastrointestinal ulceration and bleeding and of renal toxicity without added therapeutic benefit. Salicylates may also alter piroxicam exposure.
What this interaction means in plain words
Choline magnesium trisalicylate and Piroxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive inhibition of cyclooxygenase-mediated gastroprotective prostaglandins and platelet function, with possible displacement of piroxicam from protein binding.
What to do
Avoid concurrent use of two NSAIDs; choose a single agent. If unavoidable, add gastroprotection and monitor for bleeding and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Piroxicam?
MediHelp rates the interaction as major. Choline magnesium trisalicylate and Piroxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two NSAIDs raises the risk of gastrointestinal ulceration and bleeding and of renal toxicity without added therapeutic benefit. Salicylates may also alter piroxicam exposure.
How serious is the interaction between Choline magnesium trisalicylate and Piroxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two NSAIDs; choose a single agent. If unavoidable, add gastroprotection and monitor for bleeding and renal function.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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