Drug interactions
Ciclesonide inhaled + Crizotinib
Severity: Minor
Ciclesonide inhaled and Crizotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and may raise systemic exposure to the active metabolite of ciclesonide. With prolonged use this could lead to corticosteroid effects such as adrenal suppression, though inhaled exposure is low.
What this interaction means in plain words
Ciclesonide inhaled and Crizotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Crizotinib inhibits CYP3A4, reducing the clearance of ciclesonide and its active metabolite.
What to do
Usually no change is needed. Watch for signs of systemic corticosteroid excess if long-term combined use is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Ciclesonide inhaled with Crizotinib?
MediHelp rates the interaction as minor. Ciclesonide inhaled and Crizotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crizotinib inhibits CYP3A4 and may raise systemic exposure to the active metabolite of ciclesonide. With prolonged use this could lead to corticosteroid effects such as adrenal suppression, though inhaled exposure is low.
How serious is the interaction between Ciclesonide inhaled and Crizotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no change is needed. Watch for signs of systemic corticosteroid excess if long-term combined use is required.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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