Drug interactions
Ciclesonide inhaled + Itraconazole
Severity: Moderate
Ciclesonide inhaled and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole can raise systemic exposure to the active metabolite of inhaled ciclesonide. This may cause systemic corticosteroid effects such as adrenal suppression and Cushingoid features, particularly with prolonged use.
What this interaction means in plain words
Ciclesonide inhaled and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Strong CYP3A4 inhibition reduces clearance of the ciclesonide active metabolite.
What to do
Monitor for signs of corticosteroid excess and adrenal suppression during prolonged co-therapy. Consider a corticosteroid less dependent on CYP3A4, such as beclomethasone, if long-term azole therapy is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Ciclesonide inhaled with Itraconazole?
MediHelp rates the interaction as moderate. Ciclesonide inhaled and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole can raise systemic exposure to the active metabolite of inhaled ciclesonide. This may cause systemic corticosteroid effects such as adrenal suppression and Cushingoid features, particularly with prolonged use.
How serious is the interaction between Ciclesonide inhaled and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess and adrenal suppression during prolonged co-therapy. Consider a corticosteroid less dependent on CYP3A4, such as beclomethasone, if long-term azole therapy is required.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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