Drug interactions
Ciclesonide inhaled + Voriconazole
Severity: Moderate
Ciclesonide inhaled and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole can increase systemic exposure to the active metabolite of ciclesonide. Prolonged co-use could lead to corticosteroid systemic effects such as adrenal suppression.
What this interaction means in plain words
Ciclesonide inhaled and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Voriconazole inhibits CYP3A4 metabolism of ciclesonide and its active metabolite.
What to do
Monitor for signs of systemic corticosteroid excess during prolonged use. Consider a lower inhaled dose or a corticosteroid less dependent on CYP3A4.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Ciclesonide inhaled with Voriconazole?
MediHelp rates the interaction as moderate. Ciclesonide inhaled and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole can increase systemic exposure to the active metabolite of ciclesonide. Prolonged co-use could lead to corticosteroid systemic effects such as adrenal suppression.
How serious is the interaction between Ciclesonide inhaled and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of systemic corticosteroid excess during prolonged use. Consider a lower inhaled dose or a corticosteroid less dependent on CYP3A4.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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