Drug interactions
Cigarette smoking + Perphenazine
Severity: Minor
Cigarette smoking and Perphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tobacco smoke induces CYP1A2 and may modestly lower concentrations of some phenothiazines. Perphenazine is mainly cleared by CYP2D6, so the effect is likely small, but smokers may need somewhat higher doses, and stopping smoking could raise levels.
What this interaction means in plain words
Cigarette smoking and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Polycyclic aromatic hydrocarbons in smoke induce hepatic enzymes, particularly CYP1A2, increasing clearance.
What to do
Monitor clinical response and adverse effects when smoking status changes, such as on admission to smoke-free units or cessation. Adjust the perphenazine dose according to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Cigarette smoking with Perphenazine?
MediHelp rates the interaction as minor. Cigarette smoking and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tobacco smoke induces CYP1A2 and may modestly lower concentrations of some phenothiazines. Perphenazine is mainly cleared by CYP2D6, so the effect is likely small, but smokers may need somewhat higher doses, and stopping smoking could raise levels.
How serious is the interaction between Cigarette smoking and Perphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and adverse effects when smoking status changes, such as on admission to smoke-free units or cessation. Adjust the perphenazine dose according to response.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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