Drug interactions
Cilostazol + Cyclosporin
Severity: Moderate
Cilostazol and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may raise cilostazol exposure, which can increase adverse effects such as headache, tachycardia, palpitations and diarrhea. Cilostazol is contraindicated in heart failure, so excess exposure is of particular concern in cardiac patients.
What this interaction means in plain words
Cilostazol and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Cyclosporin belongs to Miscellaneous.
Why it happens
Cyclosporine inhibits CYP3A4, reducing cilostazol metabolism.
What to do
Consider reducing the cilostazol dose to 50 mg twice daily and monitor for tachycardia and other adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Cilostazol
Frequently asked questions
Can I take Cilostazol with Cyclosporin?
MediHelp rates the interaction as moderate. Cilostazol and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may raise cilostazol exposure, which can increase adverse effects such as headache, tachycardia, palpitations and diarrhea. Cilostazol is contraindicated in heart failure, so excess exposure is of particular concern in cardiac patients.
How serious is the interaction between Cilostazol and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the cilostazol dose to 50 mg twice daily and monitor for tachycardia and other adverse effects.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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