Drug interactions
Cilostazol + Dabigatran etexilate
Severity: Moderate
Cilostazol and Dabigatran etexilate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cilostazol inhibits platelet aggregation and causes vasodilation, so combining it with dabigatran increases bleeding risk. Hemorrhagic events may be more likely in older patients or those with renal impairment.
What this interaction means in plain words
Cilostazol and Dabigatran etexilate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Dabigatran etexilate belongs to Cardiovascular.
Why it happens
Additive effects on hemostasis from phosphodiesterase 3-mediated platelet inhibition and direct thrombin inhibition.
What to do
Monitor for bleeding and hemoglobin. Reassess the need for both agents regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Cilostazol
Frequently asked questions
Can I take Cilostazol with Dabigatran etexilate?
MediHelp rates the interaction as moderate. Cilostazol and Dabigatran etexilate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cilostazol inhibits platelet aggregation and causes vasodilation, so combining it with dabigatran increases bleeding risk. Hemorrhagic events may be more likely in older patients or those with renal impairment.
How serious is the interaction between Cilostazol and Dabigatran etexilate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and hemoglobin. Reassess the need for both agents regularly.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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