Drug interactions
Cilostazol + Istradefylline
Severity: Minor
Cilostazol and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily, istradefylline increases exposure to CYP3A4 substrates, which may raise cilostazol levels. The effect is not seen at 20 mg daily.
What this interaction means in plain words
Cilostazol and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cilostazol belongs to Cardiovascular; Istradefylline belongs to Central Nervous System.
Why it happens
Dose-dependent weak CYP3A4 inhibition by istradefylline.
What to do
Monitor for cilostazol adverse effects if istradefylline 40 mg is used; no adjustment is usually needed at 20 mg.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cilostazol and Istradefylline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cilostazol
Other interactions of Istradefylline
Frequently asked questions
Can I take Cilostazol with Istradefylline?
MediHelp rates the interaction as minor. Cilostazol and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At 40 mg daily, istradefylline increases exposure to CYP3A4 substrates, which may raise cilostazol levels. The effect is not seen at 20 mg daily.
How serious is the interaction between Cilostazol and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cilostazol adverse effects if istradefylline 40 mg is used; no adjustment is usually needed at 20 mg.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
