Drug interactions
Cilostazol + Nilotinib
Severity: Moderate
Cilostazol and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is a moderate CYP3A4 inhibitor and may increase cilostazol exposure. Both drugs can affect cardiac rhythm or heart rate, so higher exposure may be of concern, and nilotinib prolongs the QT interval.
What this interaction means in plain words
Cilostazol and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Nilotinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 by nilotinib reduces cilostazol clearance.
What to do
Consider reducing the cilostazol dose to 50 mg twice daily and monitor heart rate, ECG and adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Cilostazol with Nilotinib?
MediHelp rates the interaction as moderate. Cilostazol and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib is a moderate CYP3A4 inhibitor and may increase cilostazol exposure. Both drugs can affect cardiac rhythm or heart rate, so higher exposure may be of concern, and nilotinib prolongs the QT interval.
How serious is the interaction between Cilostazol and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the cilostazol dose to 50 mg twice daily and monitor heart rate, ECG and adverse effects.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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