Drug interactions
Cilostazol + Pantoprazole
Severity: Minor
Cilostazol and Pantoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pantoprazole is a weak CYP2C19 inhibitor and typically has little effect on cilostazol exposure. Omeprazole is the PPI that raises exposure to the active cilostazol metabolite, which is why the labeling recommends a dose reduction for it. For pantoprazole, a clinically meaningful change is unlikely.
What this interaction means in plain words
Cilostazol and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cilostazol belongs to Cardiovascular; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Weak CYP2C19 inhibition by pantoprazole may slightly reduce cilostazol metabolite clearance.
What to do
No routine dose change is needed. Monitor for cilostazol adverse effects such as headache or palpitations.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cilostazol
Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Cilostazol with Pantoprazole?
MediHelp rates the interaction as minor. Cilostazol and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pantoprazole is a weak CYP2C19 inhibitor and typically has little effect on cilostazol exposure. Omeprazole is the PPI that raises exposure to the active cilostazol metabolite, which is why the labeling recommends a dose reduction for it. For pantoprazole, a clinically meaningful change is unlikely.
How serious is the interaction between Cilostazol and Pantoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for cilostazol adverse effects such as headache or palpitations.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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