Drug interactions
Cilostazol + Primidone
Severity: Moderate
Cilostazol and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone, partly converted to phenobarbital, may reduce cilostazol levels and diminish its clinical effect.
What this interaction means in plain words
Cilostazol and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Primidone belongs to Central Nervous System.
Why it happens
Primidone and its phenobarbital metabolite induce CYP3A4, increasing cilostazol clearance.
What to do
Monitor claudication symptoms and consider an alternative if cilostazol response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Cilostazol with Primidone?
MediHelp rates the interaction as moderate. Cilostazol and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone, partly converted to phenobarbital, may reduce cilostazol levels and diminish its clinical effect.
How serious is the interaction between Cilostazol and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor claudication symptoms and consider an alternative if cilostazol response is lost.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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