Drug interactions
Cimetidine + Dexamethasone-neomycin-polymyxin
Severity: Minor
Cimetidine and Dexamethasone-neomycin-polymyxin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine is a weak CYP3A4 inhibitor and may modestly raise systemic dexamethasone levels. This is rarely clinically important, and topical use of the combination product gives minimal exposure.
What this interaction means in plain words
Cimetidine and Dexamethasone-neomycin-polymyxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial.
Why it happens
Weak inhibition of CYP3A4-mediated dexamethasone metabolism by cimetidine.
What to do
No routine action is needed; with prolonged high-dose systemic dexamethasone, watch for corticosteroid adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cimetidine and Dexamethasone-neomycin-polymyxin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Dexamethasone-neomycin-polymyxin?
MediHelp rates the interaction as minor. Cimetidine and Dexamethasone-neomycin-polymyxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine is a weak CYP3A4 inhibitor and may modestly raise systemic dexamethasone levels. This is rarely clinically important, and topical use of the combination product gives minimal exposure.
How serious is the interaction between Cimetidine and Dexamethasone-neomycin-polymyxin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; with prolonged high-dose systemic dexamethasone, watch for corticosteroid adverse effects.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
