Drug interactions
Cimetidine + Docetaxel
Severity: Moderate
Cimetidine and Docetaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may modestly increase docetaxel exposure, potentially worsening neutropenia, fluid retention and other dose-related toxicities. The clinical significance is uncertain because docetaxel has a narrow therapeutic window.
What this interaction means in plain words
Cimetidine and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Docetaxel belongs to Oncology.
Why it happens
Cimetidine is a weak CYP3A4 inhibitor and may decrease docetaxel metabolism.
What to do
Prefer an H2 blocker without CYP inhibition, such as famotidine, or a proton pump inhibitor during docetaxel therapy. If cimetidine is used, monitor blood counts and toxicity closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Docetaxel
Frequently asked questions
Can I take Cimetidine with Docetaxel?
MediHelp rates the interaction as moderate. Cimetidine and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine may modestly increase docetaxel exposure, potentially worsening neutropenia, fluid retention and other dose-related toxicities. The clinical significance is uncertain because docetaxel has a narrow therapeutic window.
How serious is the interaction between Cimetidine and Docetaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an H2 blocker without CYP inhibition, such as famotidine, or a proton pump inhibitor during docetaxel therapy. If cimetidine is used, monitor blood counts and toxicity closely.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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