Drug interactions
Cimetidine + Empagliflozin-metformin
Severity: Moderate
Cimetidine and Empagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine increases metformin plasma concentrations and reduces its renal clearance. This raises the risk of metformin adverse effects, including lactic acidosis in vulnerable patients.
What this interaction means in plain words
Cimetidine and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Empagliflozin-metformin belongs to Endocrine.
Why it happens
Cimetidine inhibits renal tubular secretion of metformin via OCT2 and MATE transporters.
What to do
Monitor glycemic control and renal function, and reduce the metformin dose if adverse effects occur. Consider an alternative acid suppressant such as a proton pump inhibitor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Empagliflozin-metformin?
MediHelp rates the interaction as moderate. Cimetidine and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine increases metformin plasma concentrations and reduces its renal clearance. This raises the risk of metformin adverse effects, including lactic acidosis in vulnerable patients.
How serious is the interaction between Cimetidine and Empagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and renal function, and reduce the metformin dose if adverse effects occur. Consider an alternative acid suppressant such as a proton pump inhibitor.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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