Drug interactions
Cimetidine + Erdafitinib
Severity: Minor
Cimetidine and Erdafitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib may inhibit P-glycoprotein and raise levels of P-gp substrates. Cimetidine is only a weak P-gp substrate and renal secretion is mainly via OCT/MATE, so the clinical effect is likely small.
What this interaction means in plain words
Cimetidine and Erdafitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Erdafitinib belongs to Oncology.
Why it happens
Erdafitinib is a P-gp inhibitor and may modestly increase exposure to cimetidine; the effect is predicted.
What to do
No routine action is needed; monitor for cimetidine adverse effects such as confusion in older or renally impaired patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Cimetidine with Erdafitinib?
MediHelp rates the interaction as minor. Cimetidine and Erdafitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erdafitinib may inhibit P-glycoprotein and raise levels of P-gp substrates. Cimetidine is only a weak P-gp substrate and renal secretion is mainly via OCT/MATE, so the clinical effect is likely small.
How serious is the interaction between Cimetidine and Erdafitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; monitor for cimetidine adverse effects such as confusion in older or renally impaired patients.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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