Drug interactions
Cimetidine + Fesoterodine
Severity: Minor
Cimetidine and Fesoterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may mildly increase exposure to the active metabolite of fesoterodine via CYP3A4 inhibition. Anticholinergic effects such as dry mouth, constipation, and urinary retention may be slightly increased.
What this interaction means in plain words
Cimetidine and Fesoterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Fesoterodine belongs to Genitourinary.
Why it happens
Weak CYP3A4 inhibition reduces clearance of fesoterodine's active metabolite 5-hydroxymethyl tolterodine.
What to do
No dose adjustment is generally needed; monitor for anticholinergic effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Fesoterodine
Frequently asked questions
Can I take Cimetidine with Fesoterodine?
MediHelp rates the interaction as minor. Cimetidine and Fesoterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine may mildly increase exposure to the active metabolite of fesoterodine via CYP3A4 inhibition. Anticholinergic effects such as dry mouth, constipation, and urinary retention may be slightly increased.
How serious is the interaction between Cimetidine and Fesoterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor for anticholinergic effects.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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