Drug interactions
Cimetidine + Fludrocortisone
Severity: Minor
Cimetidine and Fludrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may slightly reduce fludrocortisone clearance, but the effect is unlikely to be clinically meaningful at usual doses.
What this interaction means in plain words
Cimetidine and Fludrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Fludrocortisone belongs to Endocrine.
Why it happens
Weak CYP3A4 inhibition by cimetidine may decrease fludrocortisone metabolism.
What to do
No routine action; monitor blood pressure, potassium and edema if the fludrocortisone response changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Cimetidine with Fludrocortisone?
MediHelp rates the interaction as minor. Cimetidine and Fludrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine may slightly reduce fludrocortisone clearance, but the effect is unlikely to be clinically meaningful at usual doses.
How serious is the interaction between Cimetidine and Fludrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action; monitor blood pressure, potassium and edema if the fludrocortisone response changes.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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