Drug interactions
Cimetidine + Galantamine
Severity: Minor
Cimetidine and Galantamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine increases galantamine exposure modestly, which may enhance cholinergic effects such as nausea, vomiting and bradycardia.
What this interaction means in plain words
Cimetidine and Galantamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Galantamine belongs to Central Nervous System.
Why it happens
Cimetidine inhibits CYP3A4 and CYP2D6, which metabolize galantamine.
What to do
No routine dose change is needed. Monitor for gastrointestinal effects and bradycardia, and reduce galantamine dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Cimetidine with Galantamine?
MediHelp rates the interaction as minor. Cimetidine and Galantamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine increases galantamine exposure modestly, which may enhance cholinergic effects such as nausea, vomiting and bradycardia.
How serious is the interaction between Cimetidine and Galantamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for gastrointestinal effects and bradycardia, and reduce galantamine dose if they occur.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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