Drug interactions
Cimetidine + Glipizide-metformin
Severity: Moderate
Cimetidine and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine reduces renal tubular secretion of metformin, raising its levels and increasing the risk of adverse effects including lactic acidosis. It may also modestly enhance sulfonylurea effects.
What this interaction means in plain words
Cimetidine and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Glipizide-metformin belongs to Endocrine.
Why it happens
Cimetidine inhibits OCT2 and MATE transporters, decreasing renal clearance of metformin.
What to do
Monitor blood glucose and renal function, and consider reducing the metformin dose; use an alternative such as famotidine if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Glipizide-metformin?
MediHelp rates the interaction as moderate. Cimetidine and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine reduces renal tubular secretion of metformin, raising its levels and increasing the risk of adverse effects including lactic acidosis. It may also modestly enhance sulfonylurea effects.
How serious is the interaction between Cimetidine and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, and consider reducing the metformin dose; use an alternative such as famotidine if feasible.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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