Drug interactions
Cimetidine + Glyburide-metformin
Severity: Moderate
Cimetidine and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine reduces renal tubular secretion of metformin and raises its concentrations, which may increase the risk of adverse effects including lactic acidosis. It may also modestly enhance the effect of glyburide.
What this interaction means in plain words
Cimetidine and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Glyburide-metformin belongs to Endocrine.
Why it happens
Inhibition of renal OCT2/MATE transporters reduces metformin clearance; hepatic enzyme inhibition may also raise glyburide levels.
What to do
Monitor blood glucose and renal function and reduce the metformin dose if needed. Consider an alternative acid suppressant such as a proton pump inhibitor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cimetidine and Glyburide-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glyburide-metformin
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Glyburide-metformin?
MediHelp rates the interaction as moderate. Cimetidine and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine reduces renal tubular secretion of metformin and raises its concentrations, which may increase the risk of adverse effects including lactic acidosis. It may also modestly enhance the effect of glyburide.
How serious is the interaction between Cimetidine and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function and reduce the metformin dose if needed. Consider an alternative acid suppressant such as a proton pump inhibitor.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
