Drug interactions
Cimetidine + Ledipasvir-sofosbuvir
Severity: Moderate
Cimetidine and Ledipasvir-sofosbuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
H2-receptor antagonists raise gastric pH, which can lower ledipasvir absorption. At modest doses the effect is limited and can be managed with timing.
What this interaction means in plain words
Cimetidine and Ledipasvir-sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Ledipasvir-sofosbuvir belongs to Anti Virals.
Why it happens
Reduced gastric acidity decreases ledipasvir solubility and absorption.
What to do
Give the H2 blocker simultaneously with or 12 hours apart from ledipasvir/sofosbuvir, keeping doses at or below those equivalent to famotidine 40 mg twice daily.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Ledipasvir-sofosbuvir?
MediHelp rates the interaction as moderate. Cimetidine and Ledipasvir-sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. H2-receptor antagonists raise gastric pH, which can lower ledipasvir absorption. At modest doses the effect is limited and can be managed with timing.
How serious is the interaction between Cimetidine and Ledipasvir-sofosbuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the H2 blocker simultaneously with or 12 hours apart from ledipasvir/sofosbuvir, keeping doses at or below those equivalent to famotidine 40 mg twice daily.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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