Drug interactions
Cimetidine + Metformin-repaglinide
Severity: Moderate
Cimetidine and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine is a weak inhibitor of CYP3A4 and may modestly raise repaglinide exposure. It also reduces renal clearance of metformin, which may increase metformin levels.
What this interaction means in plain words
Cimetidine and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Metformin-repaglinide belongs to Endocrine.
Why it happens
Weak CYP3A4 inhibition reducing repaglinide clearance and inhibition of renal OCT2/MATE transport of metformin.
What to do
Monitor blood glucose and watch for hypoglycemia and metformin adverse effects; consider an alternative acid suppressant such as a proton pump inhibitor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Cimetidine and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine is a weak inhibitor of CYP3A4 and may modestly raise repaglinide exposure. It also reduces renal clearance of metformin, which may increase metformin levels.
How serious is the interaction between Cimetidine and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and watch for hypoglycemia and metformin adverse effects; consider an alternative acid suppressant such as a proton pump inhibitor.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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