Drug interactions
Cimetidine + Nateglinide
Severity: Minor
Cimetidine and Nateglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may modestly raise nateglinide levels. This could slightly increase the risk of hypoglycemia, though the effect is usually small.
What this interaction means in plain words
Cimetidine and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Nateglinide belongs to Endocrine.
Why it happens
Cimetidine inhibits CYP2C9 and CYP3A4 metabolism of nateglinide.
What to do
Monitor blood glucose when cimetidine is started or stopped and counsel the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Cimetidine with Nateglinide?
MediHelp rates the interaction as minor. Cimetidine and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine may modestly raise nateglinide levels. This could slightly increase the risk of hypoglycemia, though the effect is usually small.
How serious is the interaction between Cimetidine and Nateglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when cimetidine is started or stopped and counsel the patient on hypoglycemia symptoms.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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