Drug interactions
Cimetidine + Pazopanib
Severity: Moderate
Cimetidine and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drugs that raise gastric pH reduce the absorption of pazopanib and may lower its exposure and efficacy. This could reduce antitumor effect.
What this interaction means in plain words
Cimetidine and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Pazopanib belongs to Oncology.
Why it happens
Pazopanib has pH-dependent solubility, so H2-blocker-induced reduction in gastric acidity decreases its dissolution and absorption.
What to do
Avoid acid suppression where possible. If needed, use a short-acting antacid separated by several hours, or give the H2 blocker at bedtime with pazopanib taken in the evening fasted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cimetidine and Pazopanib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Cimetidine with Pazopanib?
MediHelp rates the interaction as moderate. Cimetidine and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drugs that raise gastric pH reduce the absorption of pazopanib and may lower its exposure and efficacy. This could reduce antitumor effect.
How serious is the interaction between Cimetidine and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid acid suppression where possible. If needed, use a short-acting antacid separated by several hours, or give the H2 blocker at bedtime with pazopanib taken in the evening fasted.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
