Drug interactions
Cimetidine + Pioglitazone
Severity: Minor
Cimetidine and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may slightly increase pioglitazone exposure, but the effect is generally small. It may marginally increase fluid retention or hypoglycemia risk.
What this interaction means in plain words
Cimetidine and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Pioglitazone belongs to Endocrine.
Why it happens
Weak inhibition of CYP2C8 and CYP3A4 metabolism of pioglitazone.
What to do
No routine adjustment is needed; monitor blood glucose and signs of edema.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Pioglitazone
Frequently asked questions
Can I take Cimetidine with Pioglitazone?
MediHelp rates the interaction as minor. Cimetidine and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine may slightly increase pioglitazone exposure, but the effect is generally small. It may marginally increase fluid retention or hypoglycemia risk.
How serious is the interaction between Cimetidine and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood glucose and signs of edema.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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