Drug interactions
Cimetidine + Praziquantel
Severity: Minor
Cimetidine and Praziquantel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine increases praziquantel plasma concentrations and prolongs its half-life. This may enhance efficacy against some parasites but could also increase dose-related adverse effects such as dizziness, headache and abdominal discomfort.
What this interaction means in plain words
Cimetidine and Praziquantel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Praziquantel belongs to Anti Parasitic.
Why it happens
Cimetidine inhibits hepatic CYP enzymes (including CYP3A4 and CYP1A2) that metabolize praziquantel.
What to do
No dose change is usually required for standard short courses; watch for increased adverse effects. Consider an alternative acid suppressant if tolerability is a concern.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Frequently asked questions
Can I take Cimetidine with Praziquantel?
MediHelp rates the interaction as minor. Cimetidine and Praziquantel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine increases praziquantel plasma concentrations and prolongs its half-life. This may enhance efficacy against some parasites but could also increase dose-related adverse effects such as dizziness, headache and abdominal discomfort.
How serious is the interaction between Cimetidine and Praziquantel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required for standard short courses; watch for increased adverse effects. Consider an alternative acid suppressant if tolerability is a concern.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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