Drug interactions
Cimetidine + Rasagiline
Severity: Moderate
Cimetidine and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine can increase rasagiline exposure because rasagiline is cleared mainly by CYP1A2. Higher levels may increase MAO-B inhibitor adverse effects such as orthostatic hypotension, dyskinesia and nausea.
What this interaction means in plain words
Cimetidine and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Rasagiline belongs to Central Nervous System.
Why it happens
Cimetidine inhibits CYP1A2-mediated metabolism of rasagiline.
What to do
Limit rasagiline to 0.5 mg daily when combined with a CYP1A2 inhibitor such as cimetidine and monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Cimetidine with Rasagiline?
MediHelp rates the interaction as moderate. Cimetidine and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine can increase rasagiline exposure because rasagiline is cleared mainly by CYP1A2. Higher levels may increase MAO-B inhibitor adverse effects such as orthostatic hypotension, dyskinesia and nausea.
How serious is the interaction between Cimetidine and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit rasagiline to 0.5 mg daily when combined with a CYP1A2 inhibitor such as cimetidine and monitor for adverse effects.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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