Drug interactions
Cimetidine + Repaglinide
Severity: Moderate
Cimetidine and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may increase repaglinide exposure and risk hypoglycemia. The effect is usually small but can matter in patients with irregular meals or renal impairment.
What this interaction means in plain words
Cimetidine and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Repaglinide belongs to Endocrine.
Why it happens
Cimetidine inhibits CYP3A4 and possibly CYP2C8, reducing repaglinide metabolism.
What to do
Monitor blood glucose and counsel on hypoglycemia symptoms; reduce the repaglinide dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Cimetidine with Repaglinide?
MediHelp rates the interaction as moderate. Cimetidine and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine may increase repaglinide exposure and risk hypoglycemia. The effect is usually small but can matter in patients with irregular meals or renal impairment.
How serious is the interaction between Cimetidine and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and counsel on hypoglycemia symptoms; reduce the repaglinide dose if needed.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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