Drug interactions
Cimetidine + Risedronate
Severity: Minor
Cimetidine and Risedronate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Raising gastric pH may speed release of delayed-release risedronate and increase its absorption, which is relevant to upper gastrointestinal irritation. The effect is formulation-specific and generally minor.
What this interaction means in plain words
Cimetidine and Risedronate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Risedronate belongs to Musculoskeletal.
Why it happens
Higher gastric pH accelerates dissolution of the pH-sensitive enteric coating of delayed-release risedronate.
What to do
With delayed-release risedronate, take it with breakfast as directed; immediate-release tablets need no change. Monitor for upper GI symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Risedronate
- Aluminum hydroxide + Risedronate Moderate
- Calcium acetate + Risedronate Moderate
- Calcium carbonate + Risedronate Moderate
- Calcium chloride + Risedronate Moderate
- Calcium citrate + Risedronate Moderate
- Calcium gluconate + Risedronate Moderate
Frequently asked questions
Can I take Cimetidine with Risedronate?
MediHelp rates the interaction as minor. Cimetidine and Risedronate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Raising gastric pH may speed release of delayed-release risedronate and increase its absorption, which is relevant to upper gastrointestinal irritation. The effect is formulation-specific and generally minor.
How serious is the interaction between Cimetidine and Risedronate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With delayed-release risedronate, take it with breakfast as directed; immediate-release tablets need no change. Monitor for upper GI symptoms.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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