Drug interactions
Cimetidine + Ropinirole
Severity: Moderate
Cimetidine and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine can increase ropinirole exposure, since ropinirole is mainly cleared via CYP1A2. This may cause more somnolence, nausea, dyskinesia, hallucinations or orthostatic hypotension.
What this interaction means in plain words
Cimetidine and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Ropinirole belongs to Central Nervous System.
Why it happens
Cimetidine inhibits CYP1A2-mediated metabolism of ropinirole.
What to do
Monitor for dopaminergic adverse effects and adjust the ropinirole dose when cimetidine is started or stopped. Famotidine is an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Frequently asked questions
Can I take Cimetidine with Ropinirole?
MediHelp rates the interaction as moderate. Cimetidine and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine can increase ropinirole exposure, since ropinirole is mainly cleared via CYP1A2. This may cause more somnolence, nausea, dyskinesia, hallucinations or orthostatic hypotension.
How serious is the interaction between Cimetidine and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dopaminergic adverse effects and adjust the ropinirole dose when cimetidine is started or stopped. Famotidine is an alternative.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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