Drug interactions
Cimetidine + Sofosbuvir-velpatasvir
Severity: Moderate
Cimetidine and Sofosbuvir-velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine raises gastric pH, and velpatasvir is poorly soluble at higher pH, so its absorption may fall. This could reduce antiviral efficacy if not managed.
What this interaction means in plain words
Cimetidine and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Sofosbuvir-velpatasvir belongs to Anti Virals.
Why it happens
H2-receptor blockade raises gastric pH and decreases velpatasvir solubility and absorption.
What to do
Give the H2 blocker simultaneously with or 12 hours apart from sofosbuvir/velpatasvir, at doses not exceeding famotidine 40 mg twice-daily equivalence.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as moderate. Cimetidine and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine raises gastric pH, and velpatasvir is poorly soluble at higher pH, so its absorption may fall. This could reduce antiviral efficacy if not managed.
How serious is the interaction between Cimetidine and Sofosbuvir-velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the H2 blocker simultaneously with or 12 hours apart from sofosbuvir/velpatasvir, at doses not exceeding famotidine 40 mg twice-daily equivalence.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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