Drug interactions
Cimetidine + Sotorasib
Severity: Moderate
Cimetidine and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib solubility falls at higher pH, so acid-reducing agents may lower its exposure. Sotorasib is also a weak P-gp inhibitor but cimetidine is not a major P-gp substrate.
What this interaction means in plain words
Cimetidine and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Sotorasib belongs to Oncology.
Why it happens
Cimetidine raises gastric pH, reducing sotorasib dissolution and absorption.
What to do
Avoid H2 antagonists if possible; if needed, take sotorasib 4 hours before or 10 hours after the H2 antagonist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Cimetidine with Sotorasib?
MediHelp rates the interaction as moderate. Cimetidine and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib solubility falls at higher pH, so acid-reducing agents may lower its exposure. Sotorasib is also a weak P-gp inhibitor but cimetidine is not a major P-gp substrate.
How serious is the interaction between Cimetidine and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid H2 antagonists if possible; if needed, take sotorasib 4 hours before or 10 hours after the H2 antagonist.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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