Drug interactions
Cimetidine + Vandetanib
Severity: Minor
Cimetidine and Vandetanib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib inhibits OCT2, which helps clear cimetidine in the kidney, so cimetidine levels may rise. The clinical effect is probably small.
What this interaction means in plain words
Cimetidine and Vandetanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Vandetanib belongs to Oncology.
Why it happens
Vandetanib inhibits OCT2-mediated renal tubular uptake and secretion of cimetidine.
What to do
No routine action is needed. Be aware that cimetidine can also raise vandetanib levels or add to QT risk, so monitor ECG per vandetanib labeling.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Cimetidine with Vandetanib?
MediHelp rates the interaction as minor. Cimetidine and Vandetanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vandetanib inhibits OCT2, which helps clear cimetidine in the kidney, so cimetidine levels may rise. The clinical effect is probably small.
How serious is the interaction between Cimetidine and Vandetanib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Be aware that cimetidine can also raise vandetanib levels or add to QT risk, so monitor ECG per vandetanib labeling.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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