Drug interactions
Cimetidine + Vincristine
Severity: Moderate
Cimetidine and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may increase vincristine exposure, potentially worsening peripheral neuropathy, constipation and other toxicities. Evidence is limited and mainly predicted from mechanism.
What this interaction means in plain words
Cimetidine and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Vincristine belongs to Oncology.
Why it happens
Cimetidine inhibits CYP3A4 metabolism of vincristine.
What to do
Use famotidine or another acid suppressant lacking CYP inhibition, and monitor for neurotoxicity and constipation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cimetidine and Vincristine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Cimetidine with Vincristine?
MediHelp rates the interaction as moderate. Cimetidine and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine may increase vincristine exposure, potentially worsening peripheral neuropathy, constipation and other toxicities. Evidence is limited and mainly predicted from mechanism.
How serious is the interaction between Cimetidine and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use famotidine or another acid suppressant lacking CYP inhibition, and monitor for neurotoxicity and constipation.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
