Drug interactions
Cimetidine + Vinorelbine
Severity: Moderate
Cimetidine and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may raise vinorelbine exposure because vinorelbine is cleared mainly through CYP3A4. Higher levels could increase myelosuppression and neurotoxicity, although clinical data are limited.
What this interaction means in plain words
Cimetidine and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Vinorelbine belongs to Oncology.
Why it happens
Cimetidine inhibits CYP3A4 (and other CYPs), reducing hepatic metabolism of vinorelbine.
What to do
Monitor blood counts and signs of neuropathy or constipation during vinorelbine therapy. Consider an alternative acid suppressant such as famotidine if cimetidine is not essential.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Vinorelbine
Frequently asked questions
Can I take Cimetidine with Vinorelbine?
MediHelp rates the interaction as moderate. Cimetidine and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine may raise vinorelbine exposure because vinorelbine is cleared mainly through CYP3A4. Higher levels could increase myelosuppression and neurotoxicity, although clinical data are limited.
How serious is the interaction between Cimetidine and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of neuropathy or constipation during vinorelbine therapy. Consider an alternative acid suppressant such as famotidine if cimetidine is not essential.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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