Drug interactions
Cinacalcet + Cortisone
Severity: Minor
Cinacalcet and Cortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cortisone is not a clinically significant CYP3A4 inducer at replacement doses, and cinacalcet has multiple clearance pathways. Any reduction in cinacalcet effect is unlikely to matter clinically.
What this interaction means in plain words
Cinacalcet and Cortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak, theoretical CYP3A4 induction by corticosteroids.
What to do
No dose change needed; follow routine serum calcium and PTH monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Cortisone?
MediHelp rates the interaction as minor. Cinacalcet and Cortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cortisone is not a clinically significant CYP3A4 inducer at replacement doses, and cinacalcet has multiple clearance pathways. Any reduction in cinacalcet effect is unlikely to matter clinically.
How serious is the interaction between Cinacalcet and Cortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change needed; follow routine serum calcium and PTH monitoring.
What other medicines interact with Cinacalcet?
MediHelp also lists interactions of Cinacalcet with, for example, Etelcalcetide, Eliglustat, Metoclopramide. The full list is on the Cinacalcet page.
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