Drug interactions
Cinacalcet + Darifenacin
Severity: Minor
Cinacalcet and Darifenacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinacalcet is a strong CYP2D6 inhibitor and darifenacin is partly cleared by CYP2D6 as well as CYP3A4, so darifenacin exposure may increase, though effect is modest.
What this interaction means in plain words
Cinacalcet and Darifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cinacalcet belongs to Miscellaneous; Darifenacin belongs to Genitourinary.
Why it happens
CYP2D6 inhibition by cinacalcet reduces darifenacin clearance.
What to do
Monitor for increased anticholinergic effects such as dry mouth and constipation; adjust the darifenacin dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darifenacin
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Darifenacin?
MediHelp rates the interaction as minor. Cinacalcet and Darifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cinacalcet is a strong CYP2D6 inhibitor and darifenacin is partly cleared by CYP2D6 as well as CYP3A4, so darifenacin exposure may increase, though effect is modest.
How serious is the interaction between Cinacalcet and Darifenacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased anticholinergic effects such as dry mouth and constipation; adjust the darifenacin dose if needed.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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