Drug interactions
Cinacalcet + Deferasirox
Severity: Moderate
Cinacalcet and Deferasirox: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox is a CYP3A4 inducer and may lower exposure to CYP3A4 substrates. Cinacalcet is metabolized by multiple enzymes including CYP3A4, so loss of effect on parathyroid hormone and calcium is possible but modest. The clinical significance is uncertain.
What this interaction means in plain words
Cinacalcet and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinacalcet belongs to Miscellaneous; Deferasirox belongs to Miscellaneous.
Why it happens
Deferasirox may induce CYP3A4, increasing the metabolism of cinacalcet.
What to do
Monitor serum calcium and PTH after starting or stopping deferasirox. Adjust the cinacalcet dose if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deferasirox
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Deferasirox?
MediHelp rates the interaction as moderate. Cinacalcet and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox is a CYP3A4 inducer and may lower exposure to CYP3A4 substrates. Cinacalcet is metabolized by multiple enzymes including CYP3A4, so loss of effect on parathyroid hormone and calcium is possible but modest. The clinical significance is uncertain.
How serious is the interaction between Cinacalcet and Deferasirox?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and PTH after starting or stopping deferasirox. Adjust the cinacalcet dose if control worsens.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
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