Drug interactions
Cinacalcet + Dexamethasone-tobramycin
Severity: Minor
Cinacalcet and Dexamethasone-tobramycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may induce CYP3A4 and slightly lower cinacalcet exposure, which could reduce its calcium-lowering effect. The effect is likely small, particularly at low systemic dexamethasone exposure.
What this interaction means in plain words
Cinacalcet and Dexamethasone-tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cinacalcet belongs to Miscellaneous; Dexamethasone-tobramycin belongs to Anti Bacterial.
Why it happens
CYP3A4 induction by dexamethasone increases cinacalcet metabolism.
What to do
Monitor serum calcium and PTH if systemic dexamethasone is given for a prolonged period and adjust cinacalcet as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Dexamethasone-tobramycin?
MediHelp rates the interaction as minor. Cinacalcet and Dexamethasone-tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone may induce CYP3A4 and slightly lower cinacalcet exposure, which could reduce its calcium-lowering effect. The effect is likely small, particularly at low systemic dexamethasone exposure.
How serious is the interaction between Cinacalcet and Dexamethasone-tobramycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and PTH if systemic dexamethasone is given for a prolonged period and adjust cinacalcet as needed.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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