Drug interactions
Cinacalcet + Dextroamphetamine transdermal
Severity: Moderate
Cinacalcet and Dextroamphetamine transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextroamphetamine is partly metabolized by CYP2D6, so cinacalcet may raise its levels. Higher amphetamine exposure increases adverse cardiovascular and CNS effects and the risk of serotonin syndrome.
What this interaction means in plain words
Cinacalcet and Dextroamphetamine transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cinacalcet inhibits CYP2D6, reducing amphetamine clearance.
What to do
Start dextroamphetamine at a low dose and titrate carefully. Monitor for serotonin syndrome, tachycardia and hypertension, and stop the patch if serotonin syndrome occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Dextroamphetamine transdermal?
MediHelp rates the interaction as moderate. Cinacalcet and Dextroamphetamine transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dextroamphetamine is partly metabolized by CYP2D6, so cinacalcet may raise its levels. Higher amphetamine exposure increases adverse cardiovascular and CNS effects and the risk of serotonin syndrome.
How serious is the interaction between Cinacalcet and Dextroamphetamine transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start dextroamphetamine at a low dose and titrate carefully. Monitor for serotonin syndrome, tachycardia and hypertension, and stop the patch if serotonin syndrome occurs.
What other medicines interact with Cinacalcet?
MediHelp also lists interactions of Cinacalcet with, for example, Etelcalcetide, Eliglustat, Metoclopramide. The full list is on the Cinacalcet page.
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