Drug interactions
Cinacalcet + Erythromycin base
Severity: Moderate
Cinacalcet and Erythromycin base: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4, one of the enzymes that metabolize cinacalcet. This may increase cinacalcet exposure and the risk of hypocalcemia and gastrointestinal effects.
What this interaction means in plain words
Cinacalcet and Erythromycin base can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 metabolism of cinacalcet by erythromycin.
What to do
Monitor serum calcium and PTH during and after erythromycin therapy and reduce the cinacalcet dose if needed. Consider a non-CYP3A4 inhibiting antibiotic for short courses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Erythromycin base?
MediHelp rates the interaction as moderate. Cinacalcet and Erythromycin base can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits CYP3A4, one of the enzymes that metabolize cinacalcet. This may increase cinacalcet exposure and the risk of hypocalcemia and gastrointestinal effects.
How serious is the interaction between Cinacalcet and Erythromycin base?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and PTH during and after erythromycin therapy and reduce the cinacalcet dose if needed. Consider a non-CYP3A4 inhibiting antibiotic for short courses.
What other medicines interact with Cinacalcet?
MediHelp also lists interactions of Cinacalcet with, for example, Etelcalcetide, Eliglustat, Metoclopramide. The full list is on the Cinacalcet page.
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