Drug interactions
Amobarbital + Cinacalcet
Severity: Moderate
Amobarbital and Cinacalcet: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital induces CYP3A4, which is one of the enzymes that clear cinacalcet, so cinacalcet exposure may fall. This could reduce its effect on parathyroid hormone and calcium.
What this interaction means in plain words
Amobarbital and Cinacalcet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Cinacalcet belongs to Miscellaneous.
Why it happens
Barbiturate induction of CYP3A4 increases cinacalcet metabolism.
What to do
Monitor serum calcium and parathyroid hormone after starting or stopping amobarbital, and titrate the cinacalcet dose to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Amobarbital with Cinacalcet?
MediHelp rates the interaction as moderate. Amobarbital and Cinacalcet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital induces CYP3A4, which is one of the enzymes that clear cinacalcet, so cinacalcet exposure may fall. This could reduce its effect on parathyroid hormone and calcium.
How serious is the interaction between Amobarbital and Cinacalcet?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and parathyroid hormone after starting or stopping amobarbital, and titrate the cinacalcet dose to response.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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