Drug interactions
Cinacalcet + Fosamprenavir
Severity: Moderate
Cinacalcet and Fosamprenavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir is converted to amprenavir, a CYP3A4 inhibitor, which can increase cinacalcet exposure. This raises the chance of hypocalcemia and gastrointestinal effects.
What this interaction means in plain words
Cinacalcet and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 by amprenavir reduces cinacalcet metabolism.
What to do
Monitor serum calcium and PTH when starting or stopping fosamprenavir. Lower the cinacalcet dose if calcium falls or adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Fosamprenavir?
MediHelp rates the interaction as moderate. Cinacalcet and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir is converted to amprenavir, a CYP3A4 inhibitor, which can increase cinacalcet exposure. This raises the chance of hypocalcemia and gastrointestinal effects.
How serious is the interaction between Cinacalcet and Fosamprenavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and PTH when starting or stopping fosamprenavir. Lower the cinacalcet dose if calcium falls or adverse effects appear.
What other medicines interact with Cinacalcet?
MediHelp also lists interactions of Cinacalcet with, for example, Etelcalcetide, Eliglustat, Metoclopramide. The full list is on the Cinacalcet page.
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