Drug interactions
Cinacalcet + Isoniazid
Severity: Minor
Cinacalcet and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinacalcet is metabolised by several CYPs including CYP3A4, so isoniazid may slightly raise its levels. Clinical effect is expected to be small and mainly shows as lower serum calcium.
What this interaction means in plain words
Cinacalcet and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cinacalcet belongs to Miscellaneous; Isoniazid belongs to Anti Bacterial.
Why it happens
Weak CYP3A4 inhibition by isoniazid decreasing cinacalcet clearance.
What to do
No routine dose change is needed. Monitor serum calcium and PTH as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cinacalcet and Isoniazid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Isoniazid
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Isoniazid?
MediHelp rates the interaction as minor. Cinacalcet and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cinacalcet is metabolised by several CYPs including CYP3A4, so isoniazid may slightly raise its levels. Clinical effect is expected to be small and mainly shows as lower serum calcium.
How serious is the interaction between Cinacalcet and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor serum calcium and PTH as usual.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
