Drug interactions
Cinacalcet + Rifampin
Severity: Moderate
Cinacalcet and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces CYP3A4 and other enzymes and may lower cinacalcet concentrations. Reduced effect could lead to loss of parathyroid hormone and calcium control.
What this interaction means in plain words
Cinacalcet and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4-mediated cinacalcet metabolism by rifampin.
What to do
Monitor serum calcium and PTH and increase the cinacalcet dose if control is lost. Reassess the dose after rifampin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Rifampin?
MediHelp rates the interaction as moderate. Cinacalcet and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin induces CYP3A4 and other enzymes and may lower cinacalcet concentrations. Reduced effect could lead to loss of parathyroid hormone and calcium control.
How serious is the interaction between Cinacalcet and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and PTH and increase the cinacalcet dose if control is lost. Reassess the dose after rifampin is stopped.
What other medicines interact with Cinacalcet?
MediHelp also lists interactions of Cinacalcet with, for example, Etelcalcetide, Eliglustat, Metoclopramide. The full list is on the Cinacalcet page.
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