Drug interactions
Cinnarizine + Pimozide
Severity: Moderate
Cinnarizine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnarizine is a sedating antihistamine and calcium channel blocker that can itself cause drowsiness and extrapyramidal symptoms. With pimozide, sedation and parkinsonian effects may be additive.
What this interaction means in plain words
Cinnarizine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinnarizine belongs to Respiratory; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression and dopamine-blocking effects.
What to do
Monitor for excessive sedation and extrapyramidal signs, and use the lowest effective doses. Consider an alternative antiemetic or vestibular agent if movement symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Cinnarizine with Pimozide?
MediHelp rates the interaction as moderate. Cinnarizine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinnarizine is a sedating antihistamine and calcium channel blocker that can itself cause drowsiness and extrapyramidal symptoms. With pimozide, sedation and parkinsonian effects may be additive.
How serious is the interaction between Cinnarizine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and extrapyramidal signs, and use the lowest effective doses. Consider an alternative antiemetic or vestibular agent if movement symptoms develop.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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