Drug interactions
Ciprofibrate + Insulin glargine
Severity: Moderate
Ciprofibrate and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fibrates can improve insulin sensitivity and lower glucose, and this may increase the effect of insulin and the risk of hypoglycemia. Low serum albumin may raise the risk further.
What this interaction means in plain words
Ciprofibrate and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fibrate effects on lipid and glucose metabolism improve insulin sensitivity, adding to insulin action; the mechanism is not fully defined.
What to do
Monitor blood glucose when ciprofibrate is started and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Frequently asked questions
Can I take Ciprofibrate with Insulin glargine?
MediHelp rates the interaction as moderate. Ciprofibrate and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fibrates can improve insulin sensitivity and lower glucose, and this may increase the effect of insulin and the risk of hypoglycemia. Low serum albumin may raise the risk further.
How serious is the interaction between Ciprofibrate and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when ciprofibrate is started and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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