Drug interactions
Insulin glargine + Insulin glargine-lixisenatide
Severity: Major
Insulin glargine and Insulin glargine-lixisenatide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination product already contains insulin glargine, so adding separate glargine duplicates the same basal insulin. This risks overdose and significant hypoglycemia.
What this interaction means in plain words
Insulin glargine and Insulin glargine-lixisenatide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin glargine belongs to Endocrine; Insulin glargine-lixisenatide belongs to Endocrine.
Why it happens
Therapeutic duplication leading to additive insulin effect.
What to do
Avoid concurrent use; count glargine from the combination product toward the total basal dose. Use a single product and monitor glucose closely if transitioning.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Insulin glargine
Frequently asked questions
Can I take Insulin glargine with Insulin glargine-lixisenatide?
MediHelp rates the interaction as major. Insulin glargine and Insulin glargine-lixisenatide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The combination product already contains insulin glargine, so adding separate glargine duplicates the same basal insulin. This risks overdose and significant hypoglycemia.
How serious is the interaction between Insulin glargine and Insulin glargine-lixisenatide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; count glargine from the combination product toward the total basal dose. Use a single product and monitor glucose closely if transitioning.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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